Molecular mechanism of a DNA double strand break generated by I-DmoI.

This video displays the molecular mechanism of a DNA double strand break generated by I-DmoI. The reaction was observed step by step by using X-ray crystallography (Molina, Stella et al., Nature Structural & Molecular Biology, 2015). Understanding how these DNA editing tools work could be used to redesign them, thus generating more specific and precise instruments recognizing and cleaving the genome in selected regions. These tools could be used in possible biomedical applications such as the one shown in the video